| 11. | Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα
Maria Russo, Rosanna Palumbo, Annalisa Mupo, Mariarosaria Tosto, Giuseppe Iacomino, Annamaria Scognamiglio, Idolo Tedesco, Giovanni Galano, Gian Luigi Russo SUMMARY: We previously demonstrated that quercetin, a naturally occurring flavonoid with strong antioxidant properties, was able to enhance programmed cell death in HPB-acute lymphoblastic leukemia CONTEXT: …antioxidants naturally present in vegetables, fruits and beverages, such as tea and wine (Middleton and Kandaswami, 1993). Although still controversial, a large number of… Oncogene 22, 3330-3342 (22 May 2003) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 12. | Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis
Alpana Tyagi, Rajesh Agarwal, Chapla Agarwal SUMMARY: A loss of functional androgen receptor and an enhanced expression of growth factor receptors and associated ligands are causal genetic events in prostate cancer CONTEXT: …serum-starved DU145 cells with epigallocatechin-3-gallate, an active compound in green tea, causes a strong increase in ERK1/2 phosphorylation via an oxidative response… Oncogene 22, 1302-1316 (06 Mar 2003) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 13. | Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate
Farrukh Afaq, Vaqar M Adhami, Nihal Ahmad, Hasan Mukhtar SUMMARY: Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, possesses significant anti-inflammatory and cancer chemopreventive properties. Studies have shown the photochemopreventive effects of green tea CONTEXT: …of UV-mediated cutaneous damages (Ames, 1983; Block, 1993; Afaq et al., 2002). Green tea is the most popular beverage consumed by more than two-thirds of the world… Oncogene 22, 1035-1044 (20 Feb 2003) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 14. | ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a
Wu Wen-Sheng SUMMARY: The signal pathway mediating induction of p15INK4b and p16INK4a during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and CONTEXT: …by antitumorigenic agents such as retinoic acid, vitamin D3, phenylacetate and green tea or cytokines such as TGF and activin were associated with the induction of various… Oncogene 22, 955-963 (20 Feb 2003) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 15. | Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells
Sanjay Gupta, Farrukh Afaq, Hasan Mukhtar SUMMARY: Apigenin, a common dietary flavonoid abundantly present in fruits and vegetables, may have the potential for prevention and therapy for prostate cancer. Here, we CONTEXT: …is widely distributed in many fruits and vegetables, including parsley, onions, orange, tea, chamomile, wheat sprouts and in some seasonings (Birt et al., 1998; Duthie and… Oncogene 21, 3727-3738 (22 May 2002) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 16. | The role of PI 3-kinase in the UVB-induced expression of c-fos
Melissa Gonzales, G Tim Bowden SUMMARY: The role of the PI 3-kinase signaling pathway in UVB-induced c-fos gene expression was investigated in a human keratinocyte cell line, HaCaT. The enzymatic CONTEXT: …in the mouse epidermal cell line JB6 was inhibited by tea polyphenols. Epigallocatechin-3-gallate is a specific tea polyphenol that inhibits UVB-induced c-fos and AP-1… Oncogene 21, 2721-2728 (17 Apr 2002) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 17. | Rho regulates p21CIP1, cyclin D1, and checkpoint control in mammary epithelial cells
Muriel Liberto, David Cobrinik, Audrey Minden SUMMARY: The small GTPase Rho is important for cell cycle progression and Ras transformation in fibroblasts. However, it is unclear whether Rho is needed for CONTEXT: …oncogenic Ras. We previously found that putative chemopreventive compounds in green tea had exactly the effects that would be expected of a Rho inhibitor, as the… Oncogene 21, 1590-1599 (01 Mar 2002) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 18. | Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells
Fengge Ren, Shaobo Zhang, Susan H Mitchell, Rachel Butler, Charles YF Young SUMMARY: Androgens via their cognate receptor may be involved in the development and progression of prostate cancer. The aim of this study was to determine CONTEXT: …showed that injections of the green tea polyphenol, (-)-epigallocatechin gallate (EGCG), the most potent component of the green tea polyphenols (GTP), rapidly reduced the… Oncogene 19, 1924-1932 (14 Apr 2000) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 19. | EGR-1 enhances tumor growth and modulates the effect of the Wilms' tumor 1 gene products on tumorigenicity
Volkher Scharnhorst, Aswin L Menke, Joline Attema, Johan Klein Haneveld, Nicole Riteco, Gert J van Steenbrugge, Alex J van der Eb, Aart G Jochemsen SUMMARY: The Wilms' tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family and is homozygously mutated or deleted in a subset of CONTEXT: …PBS and lysed in 1/2 RIPA buffer (20 mM TEA pH 7.8, 0.14 M NaCl, 0.05% DOC, 0.05% SDS, 0.05% Triton X-100) or IPB 0.7 buffer (20 mM TEA pH 7.8, 0.7 M NaCl, 0.5% NP-40, 0.2%… Oncogene 19, 791-800 (15 Feb 2000) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 20. | Novel polymorphism in p21waf1/cip1 cyclin dependent kinase inhibitor gene: association with human esophageal cancer
Rimple Bahl, Sonia Arora, Neera Nath, Meera Mathur, Nootan K Shukla, Ranju Ralhan SUMMARY: p21waf1/cip1, an important regulator of the cell cycle, binds to PCNA and acts as a mediator of the growth suppressing and apoptosis promoting functions CONTEXT: …including the consumption of red chillies, spices, polyunsaturated fats (oil), hot tea, alcohol and tobacco (chewing and/or smoking). These parameters were taken into… Oncogene 19, 323-328 (21 Jan 2000) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link |
| 21. | Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes
Weixing Chen, G Tim Bowden SUMMARY: The effects of p38 MAP kinase and ERK on UVB induced c-fos gene expression were studied in a human keratinocyte cell line, FL30. UVB CONTEXT: …(-)-Epigallocatechin gallate (EGCG), a chemoprevention agent isolated from green tea, inhibited UVB induced c-fos gene expression and AP-1 activation (Chen et al., 1999b;… Oncogene 18, 7469-7476 (10 Dec 1999) Original Article Abstract | Full Text | PDF | Rights and permissions | Save this link
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| 22. | The Rel/NF-κB signal transduction pathway: introduction
Thomas D Gilmore CONTEXT: …Indeed, many common synthetic (e.g., aspirin), and traditional (e.g., green tea, curcumin) remedies target, at least in part, the Rel/NF-B signaling pathway (Epinat and… Oncogene 18, 6842-6844 (26 Nov 1999) Original Article Full Text | PDF | Rights and permissions | Save this link
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